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Image Search Results
Journal: Frontiers in Genetics
Article Title: m6A Methylation in Cardiovascular Diseases: From Mechanisms to Therapeutic Potential
doi: 10.3389/fgene.2022.908976
Figure Lengend Snippet: m6A sequencing and microarray data in GEO related to CVD.
Article Snippet: GSE159309 ,
Techniques: Sequencing, Microarray, Next-Generation Sequencing, Methylation, Control, Dissection
Journal: Theranostics
Article Title: Single-cell analyses reveal evolution mimicry during the specification of breast cancer subtype
doi: 10.7150/thno.96163
Figure Lengend Snippet: The molecular and clinical characteristics of LP subtype breast cancer. (A) Stacked bar plot showing the deconvolution result of breast tumors from the METABRIC cohort. Colors of the bars denote three cell lineages as shown in the legend. The y axis stands for the proportion of each cell lineage in a given bulk tumor sample. Within the x axis, each column represents one tumor case. The annotation bar above denotes the molecular subtypes of bulk tumors that are defined by the dominant cell lineage within each tumor, where yellow represents the mixture of multiple cell lineages. (B) Kaplan-Meier plot showing worse clinical outcome in LP subtype patients within the METABRIC cohort. P value is calculated using the log-rank test. (C) Spearman correlation between LP score and diverse mutational signatures. Correlations with P < 0.05 are marked with an asterisk. (D) Violin plot comparing the HRD score between LP-low and LP-high breast tumors in TCGA. Unpaired two-sided Wilcoxon test. (E) Violin plot comparing the expression level of LP score of breast tumors with different responses to NAC treatment. Unpaired two-sided Wilcoxon test. (F) Violin plot comparing the expression level of LP score of breast tumors with different responses to PARP inhibitor treatment in the I-SPY2 cohort. Unpaired two-sided Wilcoxon test. (G) Bubble heatmap showing up-regulated pathways enriched in breast tumors with high LP proportion via GSEA. Dot size indicates the normalized enrichment score (NES), colored based on the adjusted P value. (H) Violin plot comparing the T cell exhausted signature score between LP-low and LP-high breast tumors in TCGA. Unpaired two-sided Wilcoxon test. (I) Violin plot comparing the expression level of LP score of breast cancer patients with different responses to anti-PD1 treatment. Unpaired two-sided Wilcoxon test. (J) Immunohistochemistry of breast tissue microarray for PSAT1, ER and CK14. (K) LP subtype of breast cancer patients with PSAT1 high /ER low /CK14 low were associated with poor DFS. P value is calculated using the log-rank test.
Article Snippet: Six series of tissue microarray were used to detect
Techniques: Expressing, Immunohistochemistry, Microarray